Spline-based self-controlled case series method
نویسندگان
چکیده
منابع مشابه
Spline-based self-controlled case series method.
The self-controlled case series (SCCS) method is an alternative to study designs such as cohort and case control methods and is used to investigate potential associations between the timing of vaccine or other drug exposures and adverse events. It requires information only on cases, individuals who have experienced the adverse event at least once, and automatically controls all fixed confoundin...
متن کاملSelf-controlled case series method: small sample performance
We derive second-order expressions for the asymptotic bias and variance of the log relative incidence estimator for the self-controlled case series method in a simplified scenario, and study in qualitative terms how bias and variance depend on factors such as the relative incidence and ratio of risk to observation period. Small-sample performance of the estimator in realistic scenarios is inves...
متن کاملTutorial in biostatistics: the self-controlled case series method.
The self-controlled case series method was developed to investigate associations between acute outcomes and transient exposures, using only data on cases, that is, on individuals who have experienced the outcome of interest. Inference is within individuals, and hence fixed covariates effects are implicitly controlled for within a proportional incidence framework. We describe the origins, assump...
متن کاملSelf-controlled case series method with smooth age effect.
The self-controlled case series method, commonly used to investigate potential associations between vaccines and adverse events, requires information on cases only and automatically controls all age-independent multiplicative confounders while allowing for an age-dependent baseline incidence. In the parametric version of the method, we modelled the age-specific relative incidence by using a pie...
متن کاملThe Self-Controlled Case Series: Recent Developments
Purpose: To describe the self-controlled cases series and review recent related methodological developments. Results: The self-controlled case series offers several advantages for active surveillance for drug safety but we also outline some key limitations. We describe approaches for addressed some of these limitations. Conclusions: The self-controlled case series model and its extensions may p...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2017
ISSN: 0277-6715
DOI: 10.1002/sim.7311